Drug
CF602 is a novel A3AR allosteric modulator that enhances the receptor activity in the presence of the native ligand. The molecule is characterized by high selectivity at the A3AR and is capable of avoiding receptor desensitization, thus magnifying the agonist activity at low doses.

Pharmacology
The activity of CF602 was examined in erectile dysfunction rat model. A single dose of CF602 showed a full recovery in erectile function.

Mechanism of Action
CF602 increase eNOS and VEGF in the cavernosal endothelial cells. CF602 repeated doses over five days of treatment showed partly reversed damage in the smooth muscle.